Click HERE to learn more.

       Click HERE and HERE to learn more.

       Click HERE to access the protocol.

Time to review highlighted PacBio webinars

SMRT Sequencing as a Service – How to Bring Long-Read Technology to Your Core Lab

In this panel discussion, service providers share their experiences in bringing PacBio Systems to their labs, from the purchasing process, through managing demand for instrument time, and describe how PacBio solutions offer customers the most informative data available.

Please click HERE to watch.

AGBT Presentation: Increasing the Solve Rate of Rare and Undiagnosed Genetic Diseases with HiFi Sequencing

In this talk, Jonas Korlach, (Chief Scientific Officer at PacBio) describes how using PacBio HiFi reads, which are greater than 99.9% accurate and up to 25 kb long, led to the detection of structural variants in examples of previously unexplained rare genetic diseases. He highlights the strength of complete, phased, high-accuracy human WGS for simultaneously yielding high-quality information about any other locus or group of loci, which results in a single genetic assay that encompasses all others.

Please click HERE to watch.

Long Reads Versus More Reads Comparing Two Sequencing Tools for Evaluating Live Biotherapeutics as microbiome interventions

In this webinar, hear from Jeanette Gehrig (Senior Scientist at Siolta Therapeutics) about how her team is leveraging PacBio metagenomic sequencing to achieve: (1) Strain-level resolution of bacteria from fecal samples, (2) More functional profiling information with less sequencing data, and (3) Multiple single contig MAGs from fecal samples, multiplexed at 3 samples per SMRT Cell 8M. She also shares real world examples, including data from a retrospective clinical trial for a live biotherapeutic product.

Please click HERE to watch.

Protocol/document Updates

Protocol/document releases from Feb 2021.

Mol Med Rep. 2021 Apr; 23(4): 251. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7893683/

Equipped with Acclaro™ Intelligence Technology Software,

full-spectrum data and advanced algorithms are used to achieve accurate nucleic acids quantification with identification of common nucleic acid contaminants like:

The concentration results of various mixtures of DNA and RNA using different approaches were compared.

•RNA contaminant is identified by Acclaro™ Intelligence Technology Software

•Acclaro-corrected DNA concentration results (Green bars) is more accurate than uncorrected result (Blue bars) 

•Eliminating the overestimation of the actual concentration of DNA in a sample.