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Pacbio Webinar @ October 14 2021(Thur)
2021-10-04 08:59:00 Source：Gene Company Limited
[Pacbio Webinar]Single-Cell Omics Sequencing Technology: The Third Generation
October 14 2021(Thur) 02:00PM HKT
Currently, there is no effective way to detect structure variations (SVs) and extra-chromosomal circular DNAs (ecDNAs) at single-cell whole-genome level. Professor Tang and his team has developed a novel third-generation sequencing platform-based single-cell whole-genome sequencing (scWGS) method named SMOOTH-seq (single-molecule real-time sequencing of long fragments amplified through transposon insertion).
They will evaluate the method for detecting CNVs, SVs, and SNVs in human cancer cell lines and a colorectal cancer sample and show that SMOOTH-seq reliably and effectively detects SVs and ecDNAs in individual cells at a shallow sequencing depth, but shows relatively limited accuracy in detection of CNVs and SNVs.
In this webinar, Professor Tang will share how SMOOTH-seq opens a new chapter in scWGS as it generates high fidelity reads of kilobases long.
SPEAKER:
Fuchou Tang, Ph.D.
Professor
BIOPIC, School of Life Sciences Peking University
Register NOW:
https://programs.pacificbiosciences.com/l/1652/2021-09-28/4335c6