(Promotion till 20, Oct 2006 )
M362429-2 Survivin 0.2 mL
Survivin is a member of the inhibitor of apoptosis (IAP) gene family which counteracts apoptosis. It has been shown to be important in cell division and its expression is controlled at the transcriptional level in a cell cycle dependent manner. Overexpression of survivin has been observed in a variety of tumor types and expression has been associated with poor prognosis. The cellular localization of survivin is nuclear and/or cytoplasmic.
M362729-2 PTEN 0.2 mL
The PTEN protein is a lipid phosphatase with tumor-suppressing abilities. Reduced expression of PTEN has been reported in a variety of malignancies, including breast(1), prostate(2) and endometrial cancer. Additionally, PTEN has been suggested as a predictive biomarker for Herceptin™ (trastuzumab) efficacy in the treatment of HER2 overexpressing breast cancer(3).
M362329-2 Tyrosinase 0.2 mL/ M362301-2 Tyrosinase 1 mL/ N163487-2 Tyrosinase RTU
Tyrosinase is a copper-glycoenzyme involved in the production of melanin pigments, including both eumelanin and pheomelanin. As a marker of melanocytic lineage, tyrosinase is localized to melanocytes which can be found on the dermal/epidermal junction of normal skin. Expression of tyrosinase is also found in melanocytic lesions including benign nevi and the majority of primary and metastatic malignant melanomas. The cellular localization of tyrosinase is cytoplasmic and/or perinuclear.
M362229-2 MAGE-C1 0.2 mL
MAGE-C1 is a member of the cancer testis (CT) family of proteins. Expression of the MAGE-C1 gene and protein has been demonstrated in normal germ cells of the testes and in a spectrum of neoplastic tissues, including breast, ovary, metastatic melanoma and endometrial carcinoma. The cellular localization of MAGE-C1 is cytoplasmic and/or nuclear.
M362529-2 Mammaglobin 0.2 mL
Mammaglobin, a 93-amino acid glycoprotein, is encoded by a gene first identified in a study directed at the isolation of novel human breast cancer-associated genes(4). Mammaglobin expression is mostly confined to breast tissue. Together with a panel of other antibodies, it is useful for the identification and classification of carcinomas of breast origin.
K536111-2 Envision™ Double staining kit
EnVision™ G|2 Doublestain System is a high-sensitivity peroxidase and alkaline-phosphatase-based 2nd generation visualization kit. The kit is intended for use in immunohistochemistry for simultaneous detection of two different antigens within same specimen, and is compatible with both rabbit and mouse primary antibodies on formalin-fixed, paraffin-embedded tissue sections and fixed cell smears.
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References
1. Perren A, Weng LP, Boag AH, Ziebold U, Thakore K, Dahia PL, et al. Immunohistochemical evidence of loss of PTEN expression in primary ductal adenocarcinomas of the breast. Am J Pathol 1999;155:1253-60.
2. McMenamin ME, Soung P, Perera S, Kaplan I, Loda M, Sellers WR. Loss of PTEN expression in paraffin-embedded primary prostate cancer correlates with high Gleason score and advanced stage. Cancer Res 1999;59:4291-6.
3. Fujita T, Doihara H, Kawasaki K, Takabatake D, Takahashi H, Washio K, et al. PTEN activity could be a predictive marker of trastuzumab efficacy in the treatment of ErbB2-overexpressing breast cancer. Br J Cancer 2006;94:247-52.
4. Watson MA, Dintzis S, Darrow CM, Voss LE, DiPersio J, Jensen R, et al. Mammaglobin expression in primary, metastatic, and occult breast cancer. Cancer Res 1999;59:3028-31.
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