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Sam®5 is a small footprint, benchtop biosensor which uses surface acoustic waves (SAW) to detect and display biomolecular interactions and kinetics in real time. This Unique technology make Sam 5 can measures the binding kinetics and affinity constants of antibodies (therapeutic monoclonals and bispecific antibodies) to membrane protein targets on whole native vital cells.
It is a single syringe fluid-based system and guides the aqueous sample for analysis over a Sensor chip support surface. The analysed substances are specifically bound to the sensor surface. The sensor chips used on Sam®5 contain five independent sensors, providing five measuring channels. Injected sample flows meanders sequentially across the five sensors and thus a single sample can be characterized for up to five different bound analytes.
The central detection unit of Sam®5 holds a single sensor chip on a sample holder and is temperature controlled. In combination with the autosampler, a complete series of unattended measurements can be set up and executed e.g. overnight or over the weekend. The autosampler has two SBS footprint positions ¡V either rack for 48 vials or 96 well plate.
Moreover, Sam®5 can be used to detect crude solution which are highly coloured, highly viscous, highly salts or high DMSO. And it also have higher performance and thoughput when compare to well-known biosensor used optical detection method such as SPR in the market.
Some applications of Sam®5 including:
Antibody Binding to Native Whole Cell
Binding Kinetics Determined with the S-sens K5 Biosensor System
Identification of Single Cancer Gene Fragments
Detection of Small Molecules
Protein Degradation
Effect of antimicrobial peptides on membrane vesicles
Properties of DNA
sam®5 vs. BIAcore 3000 Comparative Performance
For more detail, Please visit to www.saw-instruments.de and www.genehk.com
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